Two-dimensional crystallization of membrane protein complexes for structure-function studies by electron crystallography
نویسندگان
چکیده
Membrane proteins comprise one of the major challenges in structural biology. Membrane protein complexes pose particular difficulties because they not only require careful solubilization, but additionally the structural, as well as functional integrity, of the entire complex needs to be maintained. Electron crystallography of two-dimensional (2D) crystals is an important emerging approach in the study of the structure and function of membrane protein complexes.
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